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Each DuoDote Auto-Injector Dose Contains:

  • Atropine, 2.1 mg/0.7 mL
  • Pralidoxime chloride, 600 mg/2 mL

For Patients Exhibiting Mild Symptoms [1]

FIRST DOSE: In the situation of known or suspected organophosphorus poisoning, administer 1 DuoDote™ injection into the mid-lateral thigh if the patient experiences 2 or more MILD symptoms of nerve gas or insecticide exposure.

Emergency medical services personnel with mild symptoms may self-administer a single dose of DuoDote.

Wait 10 to 15 minutes for DuoDote to take effect. If, after 10 to 15 minutes, the patient does not develop any SEVERE symptoms, no additional DuoDote injections are recommended, but definitive medical care should ordinarily be sought immediately. For emergency medical services personnel who have self-administered DuoDote, an individual decision will need to be made to determine their capacity to continue to provide emergency care.

ADDITIONAL DOSES: If, at any time after the first dose, the patient develops any SEVERE symptoms, administer 2 additional DuoDote injections in rapid succession, and immediately seek definitive medical care.

Please click here to review the symptoms of mild poisoning with organophosphorus nerve agents or organophosphorus insecticides, or click here to download a multimedia training presentation which describes symptoms and dosing information.


For Patients Exhibiting Severe Symptoms [1]

If a patient has any SEVERE symptoms listed here, immediately administer 3 DuoDote injections into the patient's mid-lateral thigh in rapid succession, and immediately seek definitive medical care.*

No more than 3 doses of DuoDote should be administered unless definitive medical care (eg, hospitalization, respiratory support) is available. [1]

Emergency care of the severely poisoned individual should include removal of oral and bronchial secretions, maintenance of a patent airway, supplemental oxygen, and, if necessary, artificial ventilation.

An anticonvulsant such as diazepam may be administered to treat convulsions if suspected in the unconscious individual.† The effects of nerve agents and some insecticides can mask the motor signs of a seizure.

Close supervision of all severely poisoned patients is indicated for at least 48 to 72 hours.

Please click here to review the symptoms of severe poisoning with organophosphorus nerve agents or organophosphorus insecticides, or click here to download a multimedia training presentation which describes symptoms and dosing information.

*Limit of 3 doses is specific to the pralidoxime component of DuoDote. If necessary, additional doses of
  AtroPen® (atropine) Auto-Injector can be administered if the 3 doses of DuoDote do not produce an
  adequate response. [6]
†Diazepam is recommended in addition to DuoDote if symptoms include convulsions. Please see full prescribing
  information for Diazepam Auto-Injector (C-IV). [8]

The DuoDote™ Auto-Injector (atropine 2.1 mg/0.7 mL and pralidoxime chloride 600 mg/2 mL) is indicated for the treatment of poisoning by organophosphorus nerve agents as well as organophosphorus insecticides.

IMPORTANT SAFETY INFORMATION

The DuoDote Auto-Injector is intended as an initial treatment of the symptoms of organophosphorus insecticide or nerve agent poisonings; definitive medical care should be sought immediately. The DuoDote Auto-Injector should be administered by Emergency Medical Services personnel who have had adequate training in the recognition and treatment of nerve agent or insecticide intoxication.

Individuals should not rely solely upon agents such as atropine and pralidoxime to provide complete protection from chemical nerve agents and insecticide poisoning. Primary protection against exposure to chemical nerve agents and insecticide poisoning is the wearing of protective garments including masks designed specifically for this use. Evacuation and decontamination procedures should be undertaken as soon as possible. Medical Personnel assisting evacuated victims of nerve agent poisoning should avoid contaminating themselves by exposure to the victim's clothing.

In the presence of life-threatening poisoning by organophosphorus nerve agents or insecticides, there are no absolute contraindications to the use of the DuoDote Auto-Injector. When symptoms of poisoning are not severe, DuoDote Auto-Injector should be used with extreme caution in people with heart disease, arrhythmias, recent myocardial infarction, severe narrow angle glaucoma, pyloric stenosis, prostatic hypertrophy, significant renal insufficiency, chronic pulmonary disease, or hypersensitivity to any component of the product.

Please click here to view full prescribing information for DuoDote.

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DuoDote Auto-Injector, the DuoDote Logo, Mark I Kit, and BinaJect are trademarks of Meridian Medical Technologies™, Inc., a wholly owned subsidiary of King Pharmaceuticals®, Inc. Copyright ® 2010 Meridian Medical Technologies™, Inc., a wholly owned subsidiary of King Pharmaceuticals®, Inc. All rights reserved. MMT6193 06/2009