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Chemical Nerve Agents
Atropine and pralidoxime chloride are effective antidotes against multiple chemical nerve agents, including tabun (GA), sarin (GB), soman (GD) and VX. The effectiveness of pralidoxime chloride (as well as other oxime-class antidotes) against soman in particular is dependent upon how quickly treatment is initiated. This is due to a phenomenon called "aging," in which soman becomes irreversibly bound to molecules of the AChE enzyme. Atropine remains effective in cases of soman poisoning even after aging occurs. [4]

Please click here to learn more about specific types of organophosphorus nerve agents.


Organophosphorus Insecticides
Organophosphorus insecticides (OPIs) have been in widespread use for agricultural applications for several decades. These chemicals are active against a broad spectrum of insects and currently account for about half of all insecticides used in the United States. Among the more than 100 types of OPIs, some of those most commonly used are chlorpyrifos, methyl parathion, malathion, dimethoate, diazinon, azinphos-methyl, and fonofos. [5]

Please click here to learn more about specific types of organophosphorus insecticides.

The DuoDote™ Auto-Injector (atropine 2.1 mg/0.7 mL and pralidoxime chloride 600 mg/2 mL) is indicated for the treatment of poisoning by organophosphorus nerve agents as well as organophosphorus insecticides.

IMPORTANT SAFETY INFORMATION

The DuoDote Auto-Injector is intended as an initial treatment of the symptoms of organophosphorus insecticide or nerve agent poisonings; definitive medical care should be sought immediately. The DuoDote Auto-Injector should be administered by Emergency Medical Services personnel who have had adequate training in the recognition and treatment of nerve agent or insecticide intoxication.

Individuals should not rely solely upon agents such as atropine and pralidoxime to provide complete protection from chemical nerve agents and insecticide poisoning. Primary protection against exposure to chemical nerve agents and insecticide poisoning is the wearing of protective garments including masks designed specifically for this use. Evacuation and decontamination procedures should be undertaken as soon as possible. Medical Personnel assisting evacuated victims of nerve agent poisoning should avoid contaminating themselves by exposure to the victim's clothing.

In the presence of life-threatening poisoning by organophosphorus nerve agents or insecticides, there are no absolute contraindications to the use of the DuoDote Auto-Injector. When symptoms of poisoning are not severe, DuoDote Auto-Injector should be used with extreme caution in people with heart disease, arrhythmias, recent myocardial infarction, severe narrow angle glaucoma, pyloric stenosis, prostatic hypertrophy, significant renal insufficiency, chronic pulmonary disease, or hypersensitivity to any component of the product.

Please click here to view full prescribing information for DuoDote.

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© 2007 Meridian Medical Technologies™ Inc., a subsidiary of King Pharmaceuticals®, Inc. DuoDote™ Auto-Injector, the DuoDote logo, BinaJect™, and Mark I™ Kit are trademarks of Meridian Medical Technologies™, Inc. AtroPen® is a registered trademark of Meridian Medical Technologies™, Inc. MMT 4908 10/07®